Name | Formamidine acetate |
Synonyms | FAA ormamidine acetate FORMAMIDINE ACETATE Formamidine acetate Methanimidamide(9CI) Iminoformamide acetate IMINOFORMAMIDE ACETATE methanimidamide acetate FORMAMIDINE,ACETIC ACID FORMAMIDINE ACETATE SALT Formamidine acetate salt Methanimidamide monoacetate Formamidine acetic acid salt FORMAMIDINE ACETIC ACID SALT methyl 4-methyl-1,3-thiazole-5-carboxylate |
CAS | 3473-63-0 |
EINECS | 222-442-5 |
InChI | InChI=1/C2H4O2.CH4N2/c1-2(3)4;2-1-3/h1H3,(H,3,4);1H,(H3,2,3)/p-1 |
InChIKey | XPOLVIIHTDKJRY-UHFFFAOYSA-N |
Molecular Formula | C3H8N2O2 |
Molar Mass | 104.11 |
Density | 1.124 |
Melting Point | 158-161°C (dec.)(lit.) |
Boling Point | 250.4°C at 760 mmHg |
Flash Point | 105.3°C |
Water Solubility | 832 g/L (21 ºC) |
Solubility | 832g/l |
Vapor Presure | 0.00686mmHg at 25°C |
Appearance | White crystal |
Color | Clear colorless to light yellow |
BRN | 3563488 |
PH | 8 (400g/l, H2O, 20℃) |
Storage Condition | Store below +30°C. |
Sensitive | Hygroscopic |
MDL | MFCD00012866 |
Physical and Chemical Properties | Melting Point: 157-161°C |
Use | It is used to synthesize 4-hydroxy-5-fluoropyrimidine. |
Hazard Symbols | Xi - Irritant |
Risk Codes | R43 - May cause sensitization by skin contact R36/37/38 - Irritating to eyes, respiratory system and skin. |
Safety Description | S36/37 - Wear suitable protective clothing and gloves. S37/39 - Wear suitable gloves and eye/face protection S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S27 - Take off immediately all contaminated clothing. |
WGK Germany | 2 |
FLUKA BRAND F CODES | 3-9-21 |
TSCA | Yes |
HS Code | 29252000 |
Toxicity | LD50 orally in Rabbit: 2510 mg/kg LD50 dermal Rat > 2000 mg/kg |
EPA chemical information | Information provided by: ofmpub.epa.gov (external link) |
Use | Used to synthesize 4-hydroxy-5-fluoropyrimidine. Methyl acetate is mainly used for the synthesis of a class of biologically active compounds such as anti-tumor drugs 4-hydroxy-5-fluoropyrimidine. It can also be used to synthesize cyclohexapeptide antifungal drugs and synthesize trichloropyrimidine. |
Production method | It is obtained by condensation of triethyl orthoformate and glacial acetic acid. Add triethyl orthoformate to glacial acetic acid for heating, react with ammonia for 1.5h, precipitate white crystals, and continue to pass ammonia for half an hour. The reactants are first subjected to atmospheric distillation, and then the alcohol is evaporated by vacuum distillation. Cold to 25°C, wash, filter, and dry with absolute ethanol to obtain formamidine acetate. |
spontaneous combustion temperature | 565°C |